SHIGA TOXIN B-SUBUNIT AS A VECTOR FOR TUMOR DIAGNOSIS AND DRUG DELIVERY TO GB3 EXPRESSING TUMORS

摘要

The invention relates to new compounds for cancer therapy or diagnosis andmore specifically to the use of a non-toxic B subunit of Shiga toxin mutant asa vector for diagnostic products or drugs in over-expressing Gb3 receptorcells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)- Twherein - STxB is the Shiga Toxin B subunit or a functional equivalentthereof, - Z(n) wehrein n is 0 or 1 and when n is 1, Z is an amino-acidresidue devoidof sulfydryl group, or is a polypeptide, - Cys is the amino-acidresidue for Cysteine, - T is a molecule linked by a covalent bound to the Spart of Cys, selected in a group comprising: . agents for in vivo diagnosis, .cytotoxic agents, . prodrugs, or . enzymes for the conversion of a prodrug toa drug, - Y(m) wherein m is 0 or 1 and when m is 1, Y is a linker between Tand Cys, said linker being either cleavable or not cleavable for the releaseof T after the internalization of the hybrid compound into said cells.