SUBSTITUTED FURO 2,3-B PYRIDINE DERIVATIVES

摘要

Novel compounds of the structural formula (I) are antagonists and/or inverseagonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment,prevention and suppression of diseases mediated by the CB1 receptor. Thecompounds of the present invention are useful as centrally acting drugs in thetreatment of psychosis, memory deficits, cognitive disorders, migraine,neuropathy, neuro-inflammatory disorders including multiple sclerosis andGuillain-Barre syndrome and the inflammatory sequelae of viral encephalitis,cerebral vascular accidents, and head trauma, anxiety disorders, stress,epilepsy, Parkinson s disease, movement disorders, and schizophrenia. Thecompounds are also useful for the treatment of substance abuse disorders, thetreatment of obesity or eating disorders, as well as the treatment of asthma,constipation, chronic intestinal pseudo-obstruction, and cirrhosis of theliver.