USE OF RAPAMYCIN AND RAPAMYCIN DERIVATIVES FOR THE TREATMENT OF BONE LOSS

摘要

The present invention relates to use of a rapamycin derivative offormula I(see formula I)whereinR1 is CH3 or C3-6alkynyl,R2 is H or -CH2-CH2-OH, 3-hydroxy-2-(hydroxymethyl)-2-methyl-propanoyl ortetrazolyl,and X is =O, (H,H) or (H,OH),provided that R2 is other than H when X is =O and R1 is CH3,or a prodrug thereof when R2 is -CH2-CH2-OH,in the preparation of a pharmaceutical composition for the treatment ofabnormallyincreased bone turnover or resorption.