METHOD FOR THE DIFFERENTIATION OF HUMAN ADULT STEM CELLS INTO INSULIN-SECRETING CELLS

摘要

Disclosed is a method for differentiating human adultstem cells into insulin-secreting cells. Human adult stemcells, isolated from the subcutaneous adipose tissues aroundthe eyes, are induced to differentiate into insulin-secretingcells in a medium in the presence of cytokines and growthfactors including B27 supplement, fibroblast growth factor-2,epidermal growth factor, nicotinamide, glucagon-like peptide-1, activin A, insulin-like growth factor, betacellulin, etc.,with a glucose shift from a high concentration to a lowconcentration. Having the ability to producing insulin and C-peptide at high levels, the insulin-secreting cells can beexcellent curatives for type 1 diabetes mellitus.