Methods of regulating differentiation and treating of multiple myeloma

摘要

The present invention provides methods of regulating cellular differentiation, including differentiation of stem cells and trans-differentiation of monocytes/macrophages using agonists or antagonists of pleiotrophin or a pleiotrophin receptor, as well as related methods of treating cancers associated with pleiotrophin-regulated differentiation and angiogenesis, including, e.g., multiple myeloma.