首页> 外国专利> Derivatives of 6-(6-O-cycloalkyl or 6-NH-cycloalkyl-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as MET inhibitors

Derivatives of 6-(6-O-cycloalkyl or 6-NH-cycloalkyl-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as MET inhibitors

机译:6-(6-O-环烷基或6-NH-环烷基-三唑并哒嗪-硫烷基)苯并噻唑和苯并咪唑的衍生物,其制备,其作为药物的用途以及其作为MET抑制剂的用途

摘要

The invention relates to novel products of the formula (I) where: is a single or double bond; Ra is -O-cycloalkyl or -NH-cycloalkyl; X is S, SO or SO, A is NH or S; W is H, alkyl or COR with R being cycloalkyl; alkyl; alkoxy; O-phenyl; -O-(CH2)n-phenyl with n = 1 to 4; or NR1R2 with R1 is H or alk and R2 is H, cycloalkyl, heterocycloalkyl, or alkyl; or R1, R2 form a cycle with N optionally containing O, S, N and/or NH; wherein all of said radicals are optionally substituted; and wherein said products are in any isomer or salt form and can be used as drugs, in particular as MET inhibitors.
机译:本发明涉及式(I)的新产物,其中:是单键或双键; Ra是-O-环烷基或-NH-环烷基; X是S,SO或SO,A是NH或S; W为H,烷基或COR,R为环烷基;烷基;烷氧基邻苯基-O-(CH 2)n-苯基,n = 1至4;或NR 1 R 2,其中R 1为H或烷基且R 2为H,环烷基,杂环烷基或烷基;或R1,R2与N形成环,N任选地包含O,S,N和/或NH;其中所有所述基团是任选取代的;并且其中所述产物为任何异构体或盐形式,并且可用作药物,特别是用作MET抑制剂。

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