IMAGING DIAGNOSTIC AGENT AND EXTRACORPOREAL DIAGNOSTIC AGENT FOR INCURABLE NEUROLOGICAL DISEASES

摘要

A curcumin derivative containing fluorine atom which is represented by formula (I) [wherein R^1a and R^1b independently represent each a hydrogen atom, alkyl, acetyl or methoxycarbonyl; R²s independently represent each a fluorine atom, CHF₂-, CF₃-, CHF₂O- or CF₃O-; R³s independently represent each a hydrogen atom or a fluorine atom; and A represents alkyl, cyano, carboxyl, alkoxycarbonyl or R⁴-(CH₂)_m- (wherein R⁴ represents hydroxy, carboxy, cyano, acetyloxy, alkoxycarbonyl, alkoxyalkoxy, hydroxyalkoxy or CONR⁵R⁶ (wherein R⁵ and R⁶ independently represent each a hydrogen atom or alkyl); and m represents an integer of 1 to 5)] or a salt thereof; and an imaging diagnostic agent for diagnosing a disease in association with the accumulation of amyloid β peptide aggregates which comprises a compound having a 1,3-dicarbonyl structure, wherein said compound occurs in keto- and enol-forms and the keto-form differs from the enol-form in affinity for amyloid β peptide aggregates.