IN VITRO DIAGNOSIS/PROGNOSIS METHOD AND KIT FOR ASSESSMENT OF CHRONIC ANTIBODY MEDIATED REJECTION IN KIDNEY TRANSPLANTATION

摘要

This invention refers to the field of human medicine, and specifically to the diagnosis of the rejection state in kidney transplant recipients. More precisely, the present invention concerns a method for the in vitro diagnosis of a kidney graft rejection or non-rejection phenotype, comprising: (a) determining from a kidney grafted subject biological sample an expression profile comprising the 45 genes of Table 1 or subgroups of this list of genes as described in Tables 2, 3 and 4, (b) comparing the obtained expression profile with at least one reference expression profile, and (c) determining the graft rejection or graft non-rejection phenotype from said comparison. The present invention also relates to kits and nucleic acid microarrays for performing said method. The present invention also relates to methods of treatment of kidney transplant recipient.