PROCESS FOR THE PREPARATION OF AN ENANTIOMERICALLY PURE TRISUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVE

摘要

The present invention relates to a process for the preparation of the compound of formula 7, which process comprises: the asymmetric transfer hydrogenation of the compound of formula 4 * HX: wherein HX is as decribed in the description; in the presence of an optically active Noyori- type transfer hydrogenation catalyst, at a substrate to catalyst ratio of more than 100:1 mol equivalent; a reducing agent; and a solvent; to obtain the compound of formula 7.