MULTIFUNCTIONAL NANOPARTICLES FOR FLUORESCENCE, MR AND PET IMAGES COMPRISING MAGNETIC SILICA NANOPARTICLES DOPED WITH A NEAR-INFRARED (NIR) DYE ALLOWING COMPOSITE IMAGING OF LYMPH NODES AND DEEP ORGANS, AND A METHOD FOR SYNTHESISING THE SAME

摘要

The present invention relates to nanoparticles for lymph-node and deep-organ images, comprising nanoparticles for fluorescence, MRI and PET images comprising magnetic silica nanoparticles doped with a near-infrared (NIR) dye, and relates to the imaging of lymph nodes and images of deep organs containing multifunctional imageable nanoparticles which, in order to simultaneously resolve the shortcomings of low permeability and instability to fluorescence (photobleaching) found in fluorescent dyes of the prior art, contain a near infrared (NIR) region dye of high tissue permeability and are obtained by producing silica shells on magnetic nanoparticles, which are reactive in magnetic resonance imaging (MRI), and by then attaching ⁶⁸Ga (gallium) in such a way as to allow positron emission tomography. The nanoparticles allow simultaneous MRI, PET and fluorescence imaging of deep organs. This allows the imaging of deep organs which has not been possible using fluorescence of the prior art, and allows imaging using MRI and PET at the same time since the near infrared dye (NIR dye) is located inside the silica shell and the stability of the dye itself is increased.