首页> 外国专利> INHIBITION OF STEM CELL DIFFERENTIATION, ENHANCEMENT OF PROLIFERATION AND SELECTIVE INDUCTION OF APOPTOSIS BY WNT FACTORS

INHIBITION OF STEM CELL DIFFERENTIATION, ENHANCEMENT OF PROLIFERATION AND SELECTIVE INDUCTION OF APOPTOSIS BY WNT FACTORS

机译：WNT因子抑制干细胞分化，增强增殖和选择性诱导凋亡

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摘要

The invention relates to a method for at least in part inhibiting differentiation of stem cells in a population of mammalian cells comprising upregulating a Wnt signaling pathway to a differentiation inhibiting level in said population of cells. The invention increases at the same time the number of stem cells in a population of mammalian cells compared to a reference population, and induces at least in part apoptosis in mesenchymal cell in a population of mammalian cells The invention also discloses a method for selective differentiation of a stem cell, comprising controlling the level of Wnt pathway activation. The invention is used for the proliferation and subsequent differentiation of embryonic stem cells and lung stem cells, and for ex vivo lung explant cultivation.

机译：本发明涉及至少部分抑制哺乳动物细胞群中干细胞分化的方法，该方法包括将Wnt信号传导途径上调至所述细胞群中的分化抑制水平。与参考群体相比，本发明同时增加了哺乳动物细胞群体中干细胞的数量，并且至少部分地诱导了哺乳动物细胞群体中的间充质细胞中的细胞凋亡。本发明还公开了一种选择性分化哺乳动物细胞的方法。干细胞，包括控制Wnt途径激活的水平。本发明用于胚胎干细胞和肺干细胞的增殖和随后的分化，以及离体肺外植体的培养。 展开▼

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公开/公告号EP1689856B1

专利类型

公开/公告日2011-10-05

原文格式PDF

申请/专利权人 DELTACELL B V;
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申请/专利号EP20040808705

发明设计人 KIELMAN MENNO FREDERIK;
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申请日2004-11-11

分类号C12N5/071;

国家 EP

入库时间 2022-08-21 17:59:14

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机译： WNT因子抑制干细胞分化，增强增殖和选择性诱导凋亡

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机译： Wnt因子抑制干细胞分化，促进增殖和选择性诱导凋亡

5. INHIBITION OF STEM CELL DIFFERENTIATION, ENHANCEMENT OF PROLIFERATION AND SELECTIVE INDUCTION OF APOPTOSIS BY WNT FACTORS [P] . 欧洲知识产权局专利： EP1689856A1 . 2006-08-16

机译： WNT因子抑制干细胞分化，增强增殖和选择性诱导凋亡

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