ATTENUATED SALMONELLA VARIANT STRAIN RESULTING FROM THE GENETIC TRANSFORMATION OF ADHESIN FROM PATHOGENIC PIG ESCHERICHIA COLI AND A VACCINE COMPOSITION COMPRISING THE SAME FOR PREVENTING AND TREATING PATHOGENIC COLIBACILLOSIS AND SALMONELLOSIS IN PIGS

摘要

Provided are: a salmonella variant strain which comprises the adhesin gene from pathogenic pig Escherichia coli and in which the lon, cpxR and asd genes have been deleted; and a vaccine composition comprising the same, for preventing and treating pathogenic colibacillosis and salmonellosis in pigs. Also provided are: a production method for the salmonella variant strain; and a vaccination method for preventing or treating colibacillosis and salmonellosis in pigs, wherein the salmonella variant strain is prepared as a live or dead vaccine which is inoculated into a sow or piglet. The vaccine of the present invention can simultaneously defend against wild pathogenic Escherichia coli and salmonella bacteria since the various adhesin antigens which are expressed/secreted and the attenuated salmonella bacteria induce an immune response which is systemic and mucosal in the mucosae of the pig. Further, it has been confirmed that the vaccine of the present invention is safer and is far better in inducing an immune response and defending against pathogenic Escherichia coli than existing pathogenic pig Escherichia coli vaccines.