Therapeutic agent for depletion of an unwanted protein population from plasma

摘要

Use of a non-proteinaceous agent for the preparation of a composition for the treatment of a subject having a disorder caused by a pathogenic protein, by therapeutic depletion of the pathogenic protein from the plasma of the subject; wherein the treatment comprises administering to the subject a dosage of the agent sufficient for therapeutic depletion; wherein the agent comprises a plurality of ligands covalently co-linked so as to form a complex with a plurality of the proteins in the presence thereof; and wherein at least two of the ligands are the same or different and are capable of being bound by ligand binding sites present on the proteins.