首页>
外国专利>
APOLIPOPROTEIN A-1 MIMIC PEPTIDES, AND THERAPEUTIC AGENT FOR TREATING HYPERLIPIDEMIA AND DISEASES RELATED TO HYPERLIPIDEMIA COMPRISING SAME
APOLIPOPROTEIN A-1 MIMIC PEPTIDES, AND THERAPEUTIC AGENT FOR TREATING HYPERLIPIDEMIA AND DISEASES RELATED TO HYPERLIPIDEMIA COMPRISING SAME
展开▼
机译:载脂蛋白A-1模拟肽和治疗血脂过多和与血脂过多有关的疾病的治疗剂
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to apolipoprotein A-1 mimic peptides, and therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia comprising the same. More specifically, the apolipoprotein A-1 mimic peptides of the present invention were manufactured by modifying hydrophilic or hydrophobic face of existing 4F amphipathic peptides to produce Apo A-1 mimic peptides which specifically bind with cholesterol ester to allow high density lipoprotein content to increase, and the peptide of which phenylalanine in hydrophobic face of 4F is substituted with 2-naphtilalanine has superior cholesterol efflus capability and cognitive function for lipids to the existing 4F peptides, among the mimic peptides. Thus, the Apo A-1 mimic peptides of the present invention can be used as Apo A-1 mimic peptides and as a therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia.
展开▼