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BINDING PARTNERS WITH IMMUNOGLOBULIN DOMAINS MODIFIED TO HAVE EXTENDED HALF-LIFE
BINDING PARTNERS WITH IMMUNOGLOBULIN DOMAINS MODIFIED TO HAVE EXTENDED HALF-LIFE
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机译:将结合分子与免疫球蛋白区域进行修改以延长半衰期
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摘要
A method for conjugation of glycosylated Fc-containing proteins is described. The method comprises carbamate chemistry performed and neutral pH or below and the resulting Fc-containing protein are expected to retain tertiary structure and therefore Fc-related bioactivity such as FcR binding, the ability to bind Clq, in addition to retaining ligand binding capabilities related to the incorporation of a ligand binding peptide or other polypeptide which has binding specificity. The method is exemplified using an erythropoietin-mimetic peptide fused to a human IgG1 antibody constant domain comprising a hinge, CH2 and CH3.
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