CLASSIFICATION OF THYROID FOLLICULAR NEOPLASIA BASED ON MRNA EXPRESSION

摘要

The present invention relates to molecular classifiers based on specific m RNA expression patterns which distinguish the malignant and benign subtypes of thyroid follicular neoplasia; follicular thyroid carcinoma and follicular thyroid adenoma. The invention further relates to methods for diagnosing thyroid follicular neoplasia in samples from thyroid nodules to reduce the number of diagnostic operations and expediting surgery for individuals with a malignant nodule. Among the genes analysed are T0P2A, RRM2, PBK, ANLN, NR4A1, FOSB, EGR2 and CTGF.