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MATERIALS AND METHODS RELATED TO SODIUM/POTASSIUM ADENOSINE TRIPHOSPHATASE AND SRC
MATERIALS AND METHODS RELATED TO SODIUM/POTASSIUM ADENOSINE TRIPHOSPHATASE AND SRC
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机译:与钠/钾腺苷三磷酸磷酸酶和SRC有关的材料和方法
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摘要
This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream.
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机译:本发明部分基于对钠/钾三磷酸腺苷三磷酸合酶(Na / K ATPase)的新结构构象和功能的阐明,尤其是对新结合位点和相互作用的阐明。本发明提供了Na / K ATP酶和与Na / K ATP酶相互作用的化合物之间几种令人惊奇的结构和功能关系的实际应用。公开这些结构和关系为化学影响Na / K ATPase相互作用以及已知的上游和下游调节剂提供了见识和实用的解决方案。
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