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DISCOVERY AND APPLICATIONS OF THE PROTEOLYTIC FUNCTION OF N-TERMINAL ACETYLATION OF CELLULAR PROTEINS
DISCOVERY AND APPLICATIONS OF THE PROTEOLYTIC FUNCTION OF N-TERMINAL ACETYLATION OF CELLULAR PROTEINS
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机译:细胞蛋白N末端乙酰化蛋白水解功能的发现与应用
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摘要
Screening assays that allow for the identification of agents that modulate the activity of N -terminal acetylation of a polypeptide arid the Doa10 branch of the N-end rule pathway are provided. Also provided are methods of using an agent that modulates the activity of N- terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway to increase or decrease protein degradation in a cell, and to modulate physiologic and pathologic associated with N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway.
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