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Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus
Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus
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机译:分离的真菌启动子和基因转录终止子,以及真菌中蛋白质和化学物质的生产方法
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摘要
The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed fungus is produced by transforming a fungus with a recombinant polynucleotide molecule. The recombinant polynucleotide molecule contains an isolated polynucleotide sequence linked operably to another molecule comprising a coding region of a gene of interest. The gene regulatory element and gene transcription terminator may temporally and spatially regulate expression of particular genes for optimum production of compounds of interest in a transgenic fungus.
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