首页> 外国专利> PEPTIDE COMPOUND HAVING INHIBITORY ACTIVITY FOR INFECTION OR PROLIFERATION OF ORIENTIA TSUTSUGAMUSHI, AND PHARMACEUTICAL COMPOSITION FOR RELIEVING SCRUB TYPHUS USING SAME

PEPTIDE COMPOUND HAVING INHIBITORY ACTIVITY FOR INFECTION OR PROLIFERATION OF ORIENTIA TSUTSUGAMUSHI, AND PHARMACEUTICAL COMPOSITION FOR RELIEVING SCRUB TYPHUS USING SAME

机译:具有抑制TS虫感染或增生的肽化合物,以及使用相同的成分缓解虫的药物成分

摘要

The present invention relates to a peptide compound which is prepared on the basis of a C-terminal sequence of TSA56 of Orientia tsutsugamushi known to be involved in the infection of host cells, has an activity for bonding to fibronectin of host cells interacting with the TSA56, and has an inhibitory activity for the infection of HeLa cells, which are cervical cancer cell lines, and a pharmaceutical composition for relieving scrub typhus using the same.
机译:本发明涉及一种肽化合物,其基于已知参与宿主细胞感染的东方I虫(Orientia tsutsugamushi)的TSA56的C-末端序列制备,具有与纤连蛋白结合的活性。宿主细胞与TSA56相互作用,并具有抑制宫颈癌细胞HeLa细胞感染的活性,以及​​用于减轻斑疹伤寒的药物组合物。

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