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MODULATORS OF THE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTORS
MODULATORS OF THE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTORS
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机译:与维甲酸受体相关的ORPHAN受体的调节剂
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摘要
The invention provides small molecule modulators of retinoic acid receptor-related orphan receptors such as RORα RORβ, or RORγ. Compounds of the invention can be effective modulators at concentrations ineffective to act on LXR receptors, or on other nuclear receptors, or other biological targets. Methods of modulation the RORs and methods of treating metabolic disorders, immune disorders, cancer, and CNS disorders wherein modulation of an ROR is medically indicated are also provided.
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