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NIACIN COMPOSITIONS FOR REDUCTION OF AMYLOID BETA PEPTIDE 42 (ABETA 42) PRODUCTION AND FOR TREATMENT OF ALZHEIMER'S DISEASE (AD)
NIACIN COMPOSITIONS FOR REDUCTION OF AMYLOID BETA PEPTIDE 42 (ABETA 42) PRODUCTION AND FOR TREATMENT OF ALZHEIMER'S DISEASE (AD)
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机译:烟酸组合物,用于减少淀粉状β-肽42(ABETA 42)的生产和治疗老年痴呆症(AD)
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摘要
The present invention discloses (1) phenolic ester hybrids of niacin with m-methoxy-p-hydroxy phenyl compounds like eugenol, vanillin, apocynin, ferulic acid, isoferulic acid and eugenol epoxide and (2) cocrystals of hybrids as above, particularly cocrystal of niacin-eugenol hybrid with cocrystal former like eugenol and oxalic acid (3) novel pharmaceutical compositions comprising a combination of niacin and one or more small molecule/potentiating agent like eugenol, curcumin, cinnamic acid, meclofenamic acid, and their use in the treatment of a disorder or a disease caused by excess production of amyloid beta peptide-42 (Abeta42), its deposition, accumulation, and plaque formation including Alzheimer's Disease, dementia and mild cognitive impairment as well as other neurodegenerative diseases such as Parkinson's Disease and ischemic stroke.
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