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Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs
Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs
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机译:用于高水溶性电解质药物的水性缓释药物输送系统
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摘要
The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex comprising a pharmaceutically acceptable ion-exchange matrix and a water-soluble electrolytic drug associated with the ion-exchange matrix, wherein the surface charge of the ion-exchange matrix is opposite that of the electrolytic drug and a dispersion medium substantially free of diffusible counterions, further comprising a polyelectrolyte having the same charge as the electrolytic drug. The invention also provides methods for preparing such compositions and method of treatment.
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