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FUSION PROTEINS OF APOPTIN-PROTEIN TRANSDUCTION DOMAIN OF CARBOXYL-TERMINAL END OF EC-SOD
FUSION PROTEINS OF APOPTIN-PROTEIN TRANSDUCTION DOMAIN OF CARBOXYL-TERMINAL END OF EC-SOD
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机译:EC-SOD羧基末端的凋亡蛋白转导域融合蛋白
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摘要
Provided are fusion proteins of apoptin-protein transduction domain of carboxyl-terminus of EC-SOD, their encoding genes, the recombinant vectors containing said encoding genes, transformants containing said recombinant vectors, as well as the uses and preparation methods thereof. Especially provided are fusion proteins which fuse protein transduction domain of carboxyl-terminus of EC-SOD in the amino acid sequence of SEQ ID NO:1 or its mutants and apoptin in the amino acid sequence of SEQ ID NO:2 or its mutants, said fusion proteins have strong ability of inducing apoptosis of tumor cells, and can be used for manufacturing of medicament for the treatment of tumors.
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机译:提供EC-SOD的羧基末端的促凋亡素-蛋白转导结构域的融合蛋白,其编码基因,含有所述编码基因的重组载体,含有所述重组载体的转化体及其用途和制备方法。特别提供了融合蛋白,其融合在SEQ ID NO:1的氨基酸序列或其突变体中的EC-SOD的羧基末端的蛋白转导结构域和在SEQ ID NO:2的氨基酸序列或其突变体中的凋亡蛋白。融合蛋白具有很强的诱导肿瘤细胞凋亡的能力,可用于制造治疗肿瘤的药物。
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