2,5-BIS-ARYL-3,4-DIMETHYLTETRAHYDROFURAN LIGNANS AS AMPK ACTIVATORS, AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF METABOLIC SYNDROMES THROUGH ACTIVATION OF AMPK ENZYME CONTAINING THE SAME AS AN ACTIVE INGREDIENTS

摘要

PURPOSE: A Myristica fragrans-derived 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan is provided to activates AMP-activated protein kinase(AMPK) and to prevent and treat metabolic syndrome-associated diseases. CONSTITUTION: A Myristica fragrans extract is obtained by isolating Myristica fragrans with 10-30% of ethanol solution and contains lignin compounds of nectandrin B, nectandrin A, fragransin C1, verrucosin, saucernetin or tetrahydrofuroguaiacin. A functional food for treating obesity or metabolic syndrome contains Myristica fragrans extract.