METHOD FOR ENHANCING MESENCHYMAL STEM CELL PROLIFERATION BY KINASE INHIBITION ON TITANIUM OXIDE NANOTUBE SURFACE

摘要

PURPOSE: A method for enhancing osteoblast proliferation on a nanotube surface is provided to eliminate phenomenon of low osteoblast proliferation and to enhance the proliferation of cells using a Rho-associated kinase.;CONSTITUTION: A titanium oxide surface has a titanium oxide film formed on the surface of titanium metal or titanium alloy. An inhibitor of Rho-associated kinase enhances mesenchymal stem cell proliferation on the titanium oxide surface. The inhibitor of Rho-associated kinase is (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride or 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine monohydrochloride.;COPYRIGHT KIPO 2011