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Gastric type sustained release formulation containing pregabalin, polyethylene oxide and polyvinyl alcohol-polyethylene glycol graft copolymer
Gastric type sustained release formulation containing pregabalin, polyethylene oxide and polyvinyl alcohol-polyethylene glycol graft copolymer
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机译:包含普瑞巴林,聚环氧乙烷和聚乙烯醇-聚乙二醇接枝共聚物的胃型缓释制剂
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摘要
PURPOSE: A gastric-retentive sustained release formulation containing pregavalin, polyethyleneoxide, and polyvinylalcohol-polyethylene glycol graft copolymer is provided to control drug release and to improve swelling property and floatability. CONSTITUTION: A gastric-retentive sustained release formulation contains 100 weight parts of pregavalin or pharmaceutically acceptable salt thereof, 25-500 weight parts of polyethyleneoxide as a swelling agent, and 10-200 weight parts of polyvinyl alcohol-polyethylene glycol graft copolymer.
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