6-AMINO-N-HYDROXYHEXANAMIDE COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE USABLE AS A DRUG INHIBITING THE PROLIFERATION OF TUMOR CELLS, AND A METHOD FOR PREPARING THE SAME

摘要

PURPOSE: A 6-amino-N-hydroxyhexanamide compound is provided to ensure strong cell proliferation inhibitory power by inhibiting enzyme activity of histone deacetylase, thereby enabling use as anti-cancer drug or enzyme activity inhibitory agent of histone deacetylase.;CONSTITUTION: A compound is selected from a 6-amido-N-hydroxyhexanamide compound represented by chemical formula 1 and pharmaceutically acceptable salts thereof. In chemical formula 1, X is a single bond or selected from the group of C1-6 alkylenyl; and R is hydroxy, C3-8 cycloalkyl, C3-8 cycloalkenyl, C1-6 alkoxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, 5-7-membered aryl, 5-7-membered heteroaryl including 1-3 hetero atoms selected from N and O, and 5-7-membered heterocycloalkyl including 1-3 hetero atoms selected from N and O.;COPYRIGHT KIPO 2011