PHARMACEUTICAL COMPOSITION CONTAINING SOLANUM NIGRUM FRUIT-DERIVED ACRYLAMIDE DERIVATIVES FOR PREVENTING OR TREATING INFLAMMATORY DISEASES

摘要

PURPOSE: A pharmaceutical composition containing acrylamide derivatives is provided to suppress secretion or generation of leukotriene and to prevent and treat inflammatory diseases.;CONSTITUTION: A pharmaceutical composition for preventing or treating inflammatory diseases contains an acrylamide derivative of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. In chemical formula 1, R is hydrogen or alkoxy of C1-C4. The acrylamide derivative of chemical formula 1 is (E)-4'-hydroxy-3'-methoxystyryl 3-(4-hydroxyphenyl)propanoate or (R,E)-4'-hydroxy-3'-methoxystyryl-3-(4-hydroxyphenyl)-7-methoxypropanoate. A method for preparing the acrylamide derivatives comprises: a step of extracting Solanum nigrum with water, alcohol of C1-C4, or mixture solvent; a step of suspending the extract in the water and adding same amount of ethyl acetate to obtain an ethyl acetate fraction(first fraction); a step of performing silicagel column chromatography of the ethyl acetate fraction to obtain a second fraction(1-6); a step of performing silicagel column chromatography of the 5th fraction of the second fraction to obtain a third fraction(5-1~5-7); and a step of performing reverse phase-18 column chromatography.;COPYRIGHT KIPO 2011