HETERO-BIARYL PYRIDINE DERIVATIVE COMPOUND AND A METHOD FOR PREPARING THE SAME

摘要

PURPOSE: A method for preparing hetero-biaryl pyridine derivative compounds is provided to easily produce the compounds and to suppress tumor cell proliferation. ;CONSTITUTION: A method for preparing hetero-biaryl pyridine derivative compound of chemical formula 1 comprises a step of reacting a compound of chemical formula 2 with a compound of chemical formula 3 in a polar protic solvent under the presence of acid catalyst. The polar protic solvent is methanol, ethanol, dichloroethane, dimethyl formamide, or mixture thereof. The acid catalyst is AlCl_3, AcOH, formic acid, trifluoroacetic acid(TFA), or HCl.;COPYRIGHT KIPO 2011