POLYPEPTIDE BINDING SPECIFICALLY TO VASCULAR ENDOTHELIAL CELL GROWTH FACTOR, FUSION PROTEIN COMPRISING THEREOF AND METHOD FOR PREPARATION THEREOF

摘要

PURPOSE: A polypeptide which specifically binds to VEGF is provided to suppress binding between the VEGF and VEGF receptor and to prevent or treat cancer. CONSTITUTION: A polypeptide which suppresses binding between VEGF and VEGF receptor contains an amino acid sequence of general formula I(X1-Arg-X2-X3-Met-Trp-X4-X5-X6-X7). The polypeptide has an amino acid sequence selected from sequence numbers 1-5. A fusion protein contains the polypeptide and antibody Fc region. The Fc region is derived from human, mouse, rabbit, or goat.