SOLUBLE NANOSTRUCUTURE FOR PHOTODYNAMIC THERAPY WITH EXCELLENT WATER SOLUBILITY AND HIGH STABILITY IN HUMAN BODY

摘要

PURPOSE: A soluble nanostructure containing soluble porphyrin derivatives is provided to ensure high photodynamic therapeutic agent and to prevent side effects. ;CONSTITUTION: A soluble nanostructure for photodynamic therapy contains soluble porphyrin derivative of chemical formula 1. The porphyrin derivative is prepared by amidation of protoporphyrin IX(chemical formula 2) with polyethylene glycol derivatives(chemical formulas 3 and 4) of amino terminal. A coupling agent for amidation is 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride(EDC), N,N'-dicyclohexylcarbodiimide(DCC), or N,N'-diisopropylcarbodiimide(DIC).;COPYRIGHT KIPO 2011