A POLYMER FOR PROTEIN, POLYPEPTIDE OR PEPTIDE DRUG DELIVERY AND A METHOD FOR PREPARING THE SAME, AND A COMPOSITION FOR SUSTAINED RELEASE OF PROTEIN, POLYPEPTIDE OR PEPTIDE DRUG AND A METHOD FOR PREPARING THE SAME

摘要

PURPOSE: A polymer is provided to avoid initial excess release and toxicity and to enable constant release of drugs, thereby enabling use for sustained-release of protein, polypeptide or peptide drugs. CONSTITUTION: A polylactic acid derivative compound of chemical formula 1 has number average molecular weight of 7,000 dalton or less. In chemical formula 1, X and X' are independently hydrogen, alkyl or aryl; Y and Z are independently does not exist or alkali metal; m and n are independently an integer of 0-95 and 5 m + n 100; a and b are independently an integer of 1-6; and R is a substituted or unsubstituted -(CH2)k-, C2~10 divalent alkenyl, C6~20 divalent aryl or combination thereof, wherein k is an integer of 0-10.