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MAGNETIC FLUORESCENT NANOPARTICLE IMAGING PROBE FOR PROBING INTRACELLULAR TARGET MOLECULE

机译:用于探测细胞内靶分子的磁性荧光纳米粒子成像探针

摘要

PURPOSE: A magnetic fluorescent nanoparticle imaging probe and a composition for probing a target molecule, comprising the same are provided to diagnose and treat diseases.;CONSTITUTION: A magnetic fluorescent nanoparticle image probe for detecting a target molecule contains: a magnetic nanoparticle with a coating layer having fluorophore and bio-compatible materials; a nucleic acid probe which is conjugated to the coating layer and comprises an area which is hybridizable with the target molecules; and a molecule beacon having an oligomer which is conjugated with a quencher. The magnetic nanoparticle is a metal material, magnetic material, or magnetic alloy. The metal material is Pt, Pd, Ag, Cu, or Au. The magnetic material is Co, Mn, Fe, Ni, Gd, Mo, MM'2O4, or MpOq. The biocompatible material is silica, polymer, lipid, or dextran.;COPYRIGHT KIPO 2012
机译:目的:提供一种用于诊断和治疗疾病的磁性荧光纳米颗粒成像探针和用于探测靶分子的组合物;组成:用于检测靶分子的磁性荧光纳米颗粒成像探针包含:具有涂层的磁性纳米颗粒具有荧光团和生物相容性材料的层;核酸探针,其与涂层缀合并包括可与靶分子杂交的区域;分子信标具有与淬灭剂共轭的低聚物。磁性纳米颗粒是金属材料,磁性材料或磁性合金。金属材料是Pt,Pd,Ag,Cu或Au。磁性材料是Co,Mn,Fe,Ni,Gd,Mo,MM'2O4或MpOq。生物相容性材料是二氧化硅,聚合物,脂质或葡聚糖。; COPYRIGHT KIPO 2012

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