Biomarkers for diagnosis of aspirin hypersensitivity, a method of using the same method and aspirin hypersensitivity diagnosis

摘要

The article discloses the detection of a biomarker including a single nucleotide polymorphism (SNP) gene capable of diagnosing aspirin hypersensitivity without the administration of aspirin through analysis of the correlation between aspirin-hypersensitive asthma and SNP. Furthermore, this article demonstrates a method for manufacturing the said biomarker, likewise, a method for diagnosis of aspirin hypersensitivity using the biomarker. In order to manufacture the biomarker including a SNP gene for diagnosis of aspirin hypersensitivity, genomic DNAs of aspirin- hypersensitive patients with asthma and aspirin-nonhypersensitive patients with asthma were genotyped for one or more SNP(s), multiple regression analysis was used to correlate the SNP genotyping result with aspirin hypersensitivity, and SNPs with high correlation wereselected. Using the biomarker, aspirin-hypersensitive asthma can be effectively diagnosed without the ad¬ ministration of aspirin making it very beneficial and applicable for new drug development and diagnosis and treatment of diseases.