Composition for Suppressing Immune Response Comprising Hirsutenone as an Active Ingredient

摘要

The present invention provides a composition of an immune response suppression uses, including the imaginary Tenon as an active ingredient. It is imaginary Tenon effective component of the invention composition (ⅰ) by inhibiting the dephosphorylation of NFATc inhibits the activation of NFATc and, (ⅱ) disables the MAPKs (mitogen-activated protein kinases) in the active induced T cell (inactivation) sikimyeo, (ⅲ) inhibited the expression of the Th1 / Th2 cytokines of T cells, and has an activity to inhibit degranulation in (ⅳ) mast cell (mast cell). Therefore, the imaginary Tenon of the present invention may be useful in the treatment or prevention of autoimmune diseases due to the abnormal activation of the (undesired) T cells. In addition, imaginary Tenon the present invention is a compound extracted from a natural product is very excellent in the safety to a human body. ; Immunosuppression, imaginary Tenon (hirsutenone), T cells, β- panting sosami will kinase, calcineurin inhibitors (calcineurin inhibitor)