Preparation method of Silicon-substituted hydroxyapatite powders and coating having excellent biocompatibility

摘要

The present invention relates to a method for preparing silicon-containing single-phase apatite hydroxide (Si-HA) powder and coating layer having excellent biocompatibility, and more specifically, a step of obtaining calcium pyrophosphate by heat treating dicalcium phosphate powder ( Step 1); Performing wet milling by mixing calcium pyrophosphate powder, calcium carbonate powder and silicon dioxide powder obtained in step 1 with distilled water (step 2); And a step of heat-treating the powder obtained in step 2 (step 3), and a method for preparing silicon-containing single phase apatite hydroxide (Si-HA) powder and vacuum injection of the silicon-containing single phase apatite hydroxide (Si-HA) powder at room temperature. It relates to a method of manufacturing a coating layer using a coating process. The silicon-containing single-phase apatite hydroxide (Si-HA) powder according to the present invention contains silicone having a bone-like component and thus shows excellent biocompatibility, and there are no other phases, so that the purity is high. The prepared silicon-containing single-phase apatite hydroxide (Si-HA) coating layer provides a coating layer that is excellent in adhesion to the substrate compared to the coating layer manufactured by other methods without the change of composition between the powder and the coating layer before and after coating, and the deposition rate is fast. Therefore, it can be usefully used for medical materials requiring biocompatibility such as implants.