IPAD PROTEIN SHIGELLA AND ITS APPLICATION AS A VACCINE AGAINST SHIGELLA INFECTIONS

摘要

1. Composition for blocking the penetration of at least one Shigella serotype into a permissive cell, comprising at least one of the following components:! an IpaD polypeptide or functional derivative of the specified polypeptide; ! polynucleotide or functional fragment of the specified polynucleotide encoding the IpaD polypeptide, and / or! neutralizing anti-IpaD antibody. ! 2. A composition for treating and / or preventing Shigella infection, comprising at least one of the following components:! an IpaD polypeptide or functional derivative of the specified polypeptide; ! polynucleotide or functional fragment of the specified polynucleotide encoding the IpaD polypeptide, and / or! neutralizing anti-IpaD antibody. ! 3. A composition according to any one of claims 1 or 2, characterized in that said IpaD polypeptide has an amino acid sequence identical to or essentially the same as SEQ ID NO: 1.! 4. A composition according to any one of claims 1 or 2, characterized in that said polynucleotide has a nucleotide sequence identical to or essentially similar to SEQ ID NO: 2.! 5. The composition according to any one of claims 1 or 2, characterized in that the neutralizing anti-IpaD antibody is polyclonal. ! 6. The composition according to any one of claims 1 or 2, characterized in that the neutralizing anti-IpaD antibody is monoconal. ! 7. The composition according to any one of claims 1 or 2, further comprising a polyoside antigen. ! 8. The use of at least one of the following components to block the entry of at least one Shigella serotype into a permissive cell:! an IpaD polypeptide or functional derivative of the specified polypeptide; ! polynucleotide or its fun