AMORPHIC FORM OF N- {2-FLUOR-5- 3- (THIOFEN-2-CARBONIL) -PYRAZOLO 1,5-a PYRIMIDIN-7-IL -PHENYL} -N-METHYL-ACETAMIDE, METHOD FOR ITS PREPARATION, CONTAINING THE SPECIFIED AMORPHIC FORM PHARMACEUTICAL COMPOSITION (OPTIONS) AND MEDICINAL PRODUCT AND METHOD FOR TREATING AND / OR PREVENTION OF NERVOUS DISORDERS

摘要

1. Amorphous form of N- {2-fluoro-5- [3- (thiophen-2-carbonyl) pyrazolo [1,5-a] pyrimidin-7-yl] phenyl} -N-methyl-acetamide. ! 2. The amorphous form according to claim 1, which shows the x-ray diffraction pattern shown in figure 1.! 3. The method of obtaining the amorphous form according to any one of claims 1 to 2, comprising dissolving N- {2-fluoro-5- [3- (thiophen-2-carbonyl) -pyrazolo [1,5-a] pyrimidin-7-yl ] -phenyl} -N-methyl-acetamide in dichloromethane, evaporating the solvent in vacuo and drying the resulting product to remove residual solvent. ! 4. The method according to claim 3, in which after dissolving N- {2-fluoro-5- [3- (thiophen-2-carbonyl) -pyrazolo [1,5-a] pyrimidin-7-yl] phenyl} - Charcoal is added to the resulting solution, the resulting mixture is heated to 30-50 ° C, stirred for 20-45 min, then the resulting suspension is cooled to 15-30 ° C, charcoal is removed from it by filtration, after which the solvent is evaporated under vacuum and the resulting product is dried under vacuum at 40-60 ° C to remove residual solvent. ! 5. The method according to claim 4, in which the mixture obtained after adding charcoal to a solution of N- {2-fluoro-5- [3- (thiophene-2-carbonyl) -pyrazolo [1,5-a] pyrimidin-7 -yl] -phenyl} -N-methyl-acetamide in dichloromethane, heated to 40 ° C (± 5 ° C). ! 6. The method according to claim 4, in which the mixture obtained after adding charcoal to a solution of N- {2-fluoro-5- [3- (thiophene-2-carbonyl) -pyrazolo- [1,5-a] pyrimidine- 7-yl] phenyl} -N-methyl-acetamide in dichloromethane, stirred for 30 minutes (± 5 minutes). ! 7. The method according to claim 4, in which the resulting suspension is cooled to 20-25 ° C. ! 8. The method according to claim 4, in which the product obtained after evaporation of the solvent under vacuum is dried at 50 ° C (± 5 ° C). ! 9. The use of an amorphous form according to claim