APPLICATION OF TRIZO SUBSTITUTED COMPOUNDS OF GLYCERIN FOR TREATMENT OF HEMATOLOGICAL MALIGNANT TUMORS

摘要

New claims:! 1. The use of a trisubstituted compound of glycerol of the formula (I):! ! or its enantiomer, diastereomer or pharmaceutically acceptable salt, and at least one pharmaceutically acceptable excipient for the manufacture of a medicament for the treatment of hematological malignancies,! where X is selected from the group consisting of phosphate and sulfate; ! R1 is selected from the group consisting of alkyls with 16-20 carbon atoms; ! R2 is selected from the group consisting of alkyls with 1-3 carbon atoms and hydroxyalkyls with 1-3 carbon atoms; ! R3 is selected from the group consisting of hydrogen and alkyls with 1-3 carbon atoms; ! R4 is selected from the group consisting of alkyls with 1-3 carbon atoms and cycloalkyls with 3-6 carbon atoms; ! R5 is selected from the group consisting of hydrogen and methyl. ! 2. The use according to claim 1, where X is phosphate, R1 is - (CH2) 17-CH3, R2 is CH3, R3 is H, R4 is - (CH2) 2 - and R5 is CH3. ! 3. The use according to claim 1, where the drug is a pharmaceutical solid dosage form for oral administration, preferably an enteral dosage form. ! 4. The use according to claim 3, where the pharmaceutical solid dosage form is selected from the group consisting of tablets, pills, capsules and granules. ! 5. The use according to claim 1, where hematological malignant tumors are selected from the group consisting of leukemia, lymphoma, multiple myeloma and myelodysplastic syndrome. ! 6. The use according to claim 5, where the leukemia is selected from the group consisting of acute myelogenous leukemia, acute lymphocytic leukemia, chronic