APPLICATION 10 - (3R) -1-azabicyclo 2.2.2 OCT-3-ILMETHYL -10H-Phenothiazine for the manufacture of a medicine selectively inhibiting muscarinic receptors M1, M2 and M3

摘要

1. The use of 10 - [(3R) -1-azabicyclo [2.2.2] oct-3-ylmethyl] -10H-phenothiazine, and its pharmaceutically acceptable salts, for the manufacture of a medicament for the prevention or treatment of diseases, lesions and / or pathologies by selective inhibition of M1, M2 and M3-muscarinic receptors. ! 2. The use according to claim 1 for the manufacture of a medicament for the treatment of rhinorrhea, in particular a form adapted for nasal administration. ! 3. The use according to claim 1 for the manufacture of a medicament for preventing or treating urinary incontinence and related diseases. ! 4. The use according to one of claims 1 to 3, where 10 - [(3R) -1-azabicyclo [2.2.2] oct-3-ylmethyl] -10H-phenothiazine is a mixture selected from among mixtures containing at least 95-100% 10 - [(3R) -1-azabicyclo [2.2.2] oct-3-ylmethyl] -10H-phenothiazine, 96-100% 10 - [(3R) -1-azabicyclo [2.2.2] oct -3-ylmethyl] -10H-phenothiazine, 97-100% 10 - [(3R) -1-azabicyclo [2.2.2] oct-3-ylmethyl] -10H-phenothiazine, 98-100% 10 - [(3R) -1-azabicyclo [2.2.2] oct-3-ylmethyl] -10H-phenothiazine, 99-100% 10 - [(3R) -1-azabicyclo [2.2.2] oct-3-ylmethyl] -10H-phenothiazine and pure 10 - [(3R) -1-azabicyclo [2.2.2] oct-3-ylmethyl] -10H-phenothiazine. ! 5. The use according to claim 3, characterized in that urinary incontinence and related disorders are selected among the following: urinary incontinence during urgent urination (detrusor hyperreflective contraction), abnormal bladder contractions that occur involuntarily and cause an urgent desire to urinate; stress urinary incontinence; neurogenic bladder urinary incontinence associated with cystic sphincter dysfunction; urinary incontinence due to injury; urinary incontinence due to ectopic anastomosis of the urethra; enuresis (in children older than four