DIRECTED DELIVERY OF OXYGEN BY INTRAVENOUS OR INTERNAL ARTERIAL INFusion OF OXYGENED SOLUTIONS OF POLYMERIZED HEMOGLOBIN

摘要

1. A method of delivering oxygen to a tissue, blood vessel, organ, region of an organ or organism in a state of ischemia in a subject, comprising the step of administering to the subject an oxygenated hemoglobin solution, wherein the oxygenated hemoglobin solution comprises polymerized hemoglobin and where about 80 wt.% Or more polymerized hemoglobin is oxyhemoglobin. ! 2. The oxygenated hemoglobin solution according to claim 1, wherein about 90 wt.% Or more of the polymerized hemoglobin is oxyhemoglobin. ! 3. The oxygenated hemoglobin solution according to claim 1, wherein the polymerized hemoglobin comprises bovine hemoglobin. ! 4. The oxygenated hemoglobin solution according to claim 1, where the polymerized hemoglobin includes hemoglobin polymerized by dialdehyde. ! 5. The oxygenated hemoglobin solution according to claim 4, wherein the dialdehyde comprises glutaraldehyde. ! 6. The method according to claim 1, where the tissue is the brain, lungs, liver, pancreas, spleen, kidneys, heart, departments of the small intestine, departments of the colon, rectum, pancreas, skeletal muscle, stomach, bladder, esophagus , larynx, trachea, bronchi, glands, including sublingual, parotid, submandibular and thyroid glands. ! 7. The method according to claim 1, where the vessel is selected from the group consisting of the internal carotid, right vertebral, brachiocephalic, subclavian, axillary, deep brachial, brachial, common hepatic, own hepatic, gastroduodenal, right gastric, right gastro-omental, upper mesenteric, middle colonic, right colonic, ileo-colonic, radial, ulnar, deep palmar