首页> 外国专利> APPLICATION OF THE PEPTIDE His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe INDIVIDUALLY OR IN COMBINATION WITH THE PEPTIDE Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr -Ala-Ala-Cys-Thr-Gly-Cys-OH AS A THERAPEUTIC

APPLICATION OF THE PEPTIDE His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe INDIVIDUALLY OR IN COMBINATION WITH THE PEPTIDE Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr -Ala-Ala-Cys-Thr-Gly-Cys-OH AS A THERAPEUTIC

机译:肽His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe的单独应用或与肽-Pro-Gly-Thr-Cys-Glu-Ile-Cys-组合使用Ala-Tyr -Ala-Ala-Cys-Thr-Gly-Cys-OH作为一种治疗方法

摘要

1. The combination of peptides His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe and Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala- Ala-Cys-Thr-Gly-Cys-OH or their salts or hydrates. ! 2. The combination according to claim 1, where the peptides are contained in combination in an amount of from 30 wt.% To 70 wt.% To 70 wt.% To 30 wt.%. ! 3. The combination according to claim 1 for use in medicine. ! 4. The use of the peptide His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe or a combination according to claim 1, 2, or 3 for the preparation of a pharmaceutical composition for treatment and / or prevention of malignant tumors, autoimmune diseases, fibrosis, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and blood vessel diseases and metabolic diseases. ! 5. The use of the peptide according to claim 4, where the malignant tumor, autoimmune disease, fibrosis, inflammatory disease, neurodegenerative disease, infectious disease, lung disease, heart and vascular disease or metabolic disease are selected from AIDS, AIDS-associated diseases, HIV, sarcomas Kaposhi, lymphoma, anal dysplasia, cervical dysplasia, dementia complex, peripheral neuropathy, depression, anxiety, fatigue, anemia, thrombocytopenia, lipodystrophy, pulmonary hypertension, atro syndrome phyi, aspergillosis, atypical mycobacteriosis, bacteremia, candidiasis, HCMV infection, cryptococcosis, cryptosporidiosis, enteritis, histoplasmosis, nocardiosis, encephalitis, progressive multifocal leukoencephalopathy, pneumonia, toxoplasmosis, tuberculosis. ! 6. The use of the peptide His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe for the preparation of the composition for oral administration to newborns, toddlers and / or preschool children. ! 7. Note
机译:1.肽His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe和Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-的组合Ala-Ala-Cys-Thr-Gly-Cys-OH或它们的盐或水合物。 ! 2.根据权利要求1的组合,其中所述肽的组合含量为30重量%至70重量%至70重量%至30重量%。 ! 3.根据权利要求1的组合,用于医学。 ! 4.根据权利要求1、2或3的肽His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe或组合的用途,用于制备药物用于治疗和/或预防恶性肿瘤,自身免疫性疾病,纤维化,炎性疾病,神经退行性疾病,传染性疾病,肺部疾病,心脏和血管疾病以及代谢性疾病的组合物。 ! 5.根据权利要求4的肽的用途,其中所述恶性肿瘤,自身免疫性疾病,纤维化,炎性疾病,神经退行性疾病,感染性疾病,肺部疾病,心脏和血管疾病或代谢性疾病选自AIDS,与AIDS相关的疾病,HIV,肉瘤Kaposhi,淋巴瘤,肛门发育不良,宫颈发育不良,痴呆症,周围神经病,抑郁症,焦虑症,疲劳,贫血,血小板减少症,脂代谢障碍,肺动脉高压,萎缩性肌萎缩症,曲霉病,非典型分枝杆菌病,菌血症,念珠菌病,隐球菌病,隐孢子虫病,肠炎,组织胞浆菌病,心肌病,脑炎,进行性多灶性白质脑病,肺炎,弓形虫病,肺结核。 ! 6.肽His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe的用途,用于制备用于新生儿,学步儿童和/或学龄前儿童的口服组合物。 ! 7.注意

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