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APPLICATION OF MELANOTROPINSTIMULATING FACTOR AS A THERAPEUTIC MEDICINE

机译:促黑素刺激因子在治疗药物中的应用

摘要

1. The use of the Lys-Lys-Gly-Glu-OH peptide for the manufacture of a pharmaceutical composition for the treatment and / or prophylaxis of a malignant tumor, autoimmune diseases, fibrosis, inflammatory diseases, infectious diseases, lung diseases, heart and blood vessel diseases and metabolic diseases. ! 2. The use of the peptide according to claim 1, where the malignant tumor, autoimmune disease, fibrosis, inflammatory disease, infectious disease, lung disease, heart and vascular disease or metabolic disease are selected from shock and tissue damage, vascular permeability syndrome, acute respiratory distress - syndrome, gastrointestinal necrosis, acute renal tubule necrosis, adrenal hemorrhage, anorexia, hepatosplenomegaly, subendocardial inflammation, insulin resistance, l pulmonary hypertension, sarcoidosis, pulmonary fibrosis and / or COPD. ! 3. The use of the peptide according to claim 1 or 2 to obtain a composition for oral administration to newborns, toddlers and / or preschool children. ! 4. The use of the peptide according to claim 1 or 2 to obtain a lyophilized composition or a buffer liquid composition. ! 5. A pharmaceutical composition comprising a Lys-Lys-Gly-Glu-OH peptide in association with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotector, excipient and / or diluent. ! 6. The pharmaceutical composition according to claim 5 in the form of a lyophilisate or a liquid buffer solution. ! 7. The pharmaceutical composition according to claim 5 or 6, suitable for intravenous administration, oral administration or for administration by inhalation. ! 8. Pharmaceutical Compound
机译:1. Lys-Lys-Gly-Glu-OH肽在制备用于治疗和/或预防恶性肿瘤,自身免疫性疾病,纤维化,炎性疾病,感染性疾病,肺部疾病,心脏的药物组合物中的用途以及血管疾病和代谢疾病。 ! 2.根据权利要求1所述的肽的用途,其中所述恶性肿瘤,自身免疫性疾病,纤维化,炎性疾病,感染性疾病,肺部疾病,心脏和血管疾病或代谢性疾病选自休克和组织损伤,血管通透性综合征,急性呼吸窘迫-综合征,胃肠道坏死,急性肾小管坏死,肾上腺出血,厌食,肝脾肿大,心内膜下炎症,胰岛素抵抗,l肺动脉高压,结节病,肺纤维化和/或COPD。 ! 3.根据权利要求1或2所述的肽在获得用于新生儿,学步儿童和/或学龄前儿童的口服给药的组合物中的用途。 ! 4.根据权利要求1或2的肽在获得冻干组合物或缓冲液组合物中的用途。 ! 5.一种药物组合物,其包含Lys-Lys-Gly-Glu-OH肽以及至少一种药学上可接受的载体,冷冻保护剂,冻干保护剂,赋形剂和/或稀释剂。 ! 6.根据权利要求5的药物组合物,其为冻干物或液体缓冲溶液的形式。 ! 7.根据权利要求5或6所述的药物组合物,其适合于静脉内,口服或通过吸入给药。 ! 8.药物化合物

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