SYNTHESIS AND USE OF TETRAHYDROPYROLLO3,2-cPYRIDIN-4-ONE DERIVATIVES TO TREAT OBESITY, PSYCHIATRIC AND NEUROLOGICAL DISORDERS

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to the following compounds: 4-[1-(2-chlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl ether 3,3,3-trifluoropropane-1-sulphonic acid; 4-[1-(2,4-dichlorophenyl)-3-methyl-4-oxo-5-piperidin-1-yl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]phenyl ether 3,3,3-trifluoropropane-1-sulphonic acid; 4-[1-(2-chloro-4-fluorophenyl)-3-methyl-4-oxo-5-piperidin-1 -yl-4,5,6,7-tetrahydro-1 H-pyrrolo[3,2-c]pyridin-2-yl] phenyl ether 3,3,3-trifluoropropane-1-sulphonic acid; 1-(2-chlorophenyl)-3-methyl-5-piperidin-1-yl-2-[4-(4,4,4-trifluorobutoxy)phenyl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one; a pharmaceutical composition based on said compounds, having CB₁(cannabinoid)-modulator activity, as well as use of said compounds in preparing a medicinal agent for treating diabetes or obesity.;EFFECT: possibility of using compounds in treating psychiatric and neurological disorders.;7 cl, 15 ex