METHOD OF MODIFYING SPIDER SILK PROTEIN, MODIFIED SPIDER SILK PROTEIN, NUCLEIC ACID SEQUENCE CODING SAID PROTEIN, VECTOR AND HOST CELL FOR EXPRESSION THEREOF

摘要

FIELD: chemistry.;SUBSTANCE: recombinant technique is used to produce proteins consisting of the module SEQ ID NO: 3, involving replacement of serine and/or glutamate with lysine and/or cysteine and/or addition of the amino-terminal TAG according to SEQ ID NO:20-24 or carboxy-terminal TAG according to SEQ ID NO:25-28, which contain lysine or cysteine along with other amino acids.;EFFECT: invention enables to obtain modified spider silk protein, capable of binding with other substances through a lysine or cysteine residue with preservation of structural integrity of the spider silk protein.;21 cl, 8 dwg, 2 tbl, 1 ex