METHOD OF TREATING INFILTRATIVE PULMONARY TUBERCULOSIS INDUCED BY MULTIPLE-DRUG-RESISTANT AND HIGHLY TOXIC STRAINS OF MYCOBACTERIA TUBERCULOSIS

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to phthisiology, and can be used for treatment of infiltrative pulmonary tuberculosis (IPT), induced by multiple-drug-resistant and highly toxic strains of Mycobacteria tuberculosis (MDR MBT). In case if multiple drug resistance of Mycobacteria tuberculosis is determined, patient is administered fluoroquinolones and isoniazid intravenously, as well as prednisolone in dose 25-30 mg during 1.5 months. After that carried out is intensive therapy regimen with correction of isoniazid dose - in case of drug resistance to small concentrations, isoniazid is introduced intravenously in dose 15 mg/kg, in case of drug resistance to medium and high concentrations - in dose 20 mg/kg in two steps - intravenously and per os 0.3 g with 5-6 hour interval, in case if highly toxic properties of mycobacteria are confirmed, intensive therapy regimen is prolonged to 8-10 months.;EFFECT: application of invention makes it possible to increase efficiency of treatment of IPT induced by MDR MBT due to carrying out optimal correction of chemotherapy regimen and terms of intensive phase of treatment.;2 tbl, 1 ex