TREATMENT AND PREVENTION OF BENIGN NEVUS PIGMENTOSIS (NEVUSES) BY MEANS OF ARTEMISININ AND ITS DERIVATIVES

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention relates to medicine. Benign nevus pigmentosis of skin can be treated by local application, in particular, external application, of composition of active ingredients of formula (I), where in formula (I) X is CO, CHOZ or CHNRZ, where Z is selected from hydrogen; unbranched or branched (C₁-C₆) alkyl; unbranched or branched (C₂-C₆) alkenyl; unbranched or branched (C₂-C₆) alkinyl, (C₃-C₈) cycloalkyl; (C₆-C₂₄) aryl; (C₇-C₂₄) aralkyl; m- and n-CH₂(C₆H₄)COOM; COR³; CSR³; C(NR⁶)R³; SOR⁴; SO₂OM; SO₂NR⁷R⁸; SO₂O-artemisinyl; SO₂NH- artemisinyl; POR⁴R⁵ and PSR⁴R⁵; where R³ is unbranched or branched (C₁-C₆) alkyl; unbranched or branched (C₂-C₆) alkoxy; unbranched or branched (C₂-C₆) alkenyl; unbranched or branched (C₂-C₆) alkinyl; (C₃-C₈) cycloalkyl; (C₆-C₂₄) aryl; (C₆-C₁₀) aryloxy; (C₇-C₂₄) aralkyl; -(CH₂)_n-COOM, where n it is integer from 1 to 6; or 10α-di-hydro artemisinyl; R⁴ and R⁵ are selected independently on each other from unbranched or branched (C₁-C₆) alkyl; unbranched or branched (C₂-C₆) alkenyl; unbranched or branched (C₂-C₆) alkinyl; (C₃-C₈) cycloalkyl; (C₆-C₂₄) aryl; (C₇-C₂₄) aralkyl; OM; unbranched or branched (C₁-C₆) alkoxy; (C₆-C₁₀) aryloxy and NR⁷ R⁸; R⁶ are selected from unbranched or branched (C₁-C₆) alkyl; unbranched or branched (C₂-C₆) alkenyl; unbranched or branched (C₂-C₆) alkinyl; (C₃-C₈) cycloalkyl; (C₆-C₂₄) aryl and (C₇-C₂₄) aralkyl; M is hydrogen or pharmaceutically acceptable cation; and R⁷ and R⁸ are independently on each other hydrogen or unbranched or branched (C₁-C₆) alkyl, or R⁷ and R⁸ together form (C₄-C₆) alkylene bridge; and R is selected from hydrogen and groups, listed for R⁶ . These compounds are also effective in prevention of acquired nevuses from nevoid cells.;EFFECT: during treatment with formula (1) compounds healthy tissue is not damaged, and treatment is painless and simple.;26 cl, 1 tbl, 10 ex