reagents and methods for the determination of pk / adme - tox properties of new chemical entities and wirkstoffkandidaten

摘要

Methods using colloidal conductive polymers, noble metal nanoparticles or of stable metal/conductive polymer composite colloids as reagents for at least the in vitro prediction of, if not the determination of, PK/ADME-tox properties of new chemical entities (NCEs) are provided. Also provided are kits that include the subject methods and reagents for application thereof. The salient characteristicsof these methods and reagents pertaining to the present invention reside in the fact that the reactions in which they are involved are homogeneous, rapid, and proceed as 'mix and read' processes.