permselektive, asymmetric hohlfasermembran for separation of toxic mediators from blood

摘要

The invention relates to a permselective asymmetric hollow fibre membrane for the treatment of sepsis, especially systemic inflammatory response syndrome, multiorgan system dysfunction syndrome and/or multiorgan system failure, wherein the membrane allows passage of molecules having a molecular weight of up to 45 kDa with a sieving coefficient of 0.1-1.0 in presence of whole blood, and has a molecular weight exclusion limit in water of about 200 kDa.